April 30, 2020

Clinical Reports

  • Pulmonary Embolism and Increased Levels of d-Dimer in Patients with Coronavirus Disease
    Authors report 3 patients with coronavirus disease who had a decline in respiratory status during their hospital course that responded well to intravenous steroids and interleukin-6 receptor antagonist therapy. These patients later showed development of persistent hypoxia with increased levels of d-dimer levels and were given a diagnosis of pulmonary embolisms.

Antiviral Therapeutics & Vaccines

  • Adaptive COVID-19 Treatment Trial “ACTT” (NIAID)

    RESULTS (N=1063)

    • Primary Endpoint: Median time to recovery was 11 days for patients treated with remdesivir compared with 15 days for those who received placebo (p<0.001)
    • Mortality rate of 8.0% for the group receiving remdesivir versus 11.6% for the placebo group (NS, p=0.059) 
  • SIMPLE I Trial results (Gilead)

    RESULTS (N~400)

    • Similar improvement in clinical status for 5-day course vs 10-day course of treatment

    No placebo control

  • Remdesivir in Chinese adults with severe COVID-19

    RESULTS (237 patients were enrolled and randomly assigned to a treatment group; 158 to remdesivir and 79 to placebo)

    • Stopped prior to full enrollment due to slow patient enrollment
    • Remdesivir use was not associated with a difference in time to clinical improvement (hazard ratio 1·23 [95% CI 0·87–1·75]).
    • Mortality 14% Remdesivir, 13% placebo
    • Remdesivir did not result in significant reductions in SARS-CoV-2 RNA loads compared to placebo in upper respiratory tract or sputum specimens

     

Situation Dashboards

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World Health Organization (WHO)

Novel Coronavirus (COVID-19) Situation from World Health Organization (WHO)
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Johns Hopkins University (JHU)

Coronavirus COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at JHU
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COVID-19 in US and Canada

1Point3Acres Real-Time Coronavirus (COVID-19) Updates in US and Canada with Credible Sources
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Genomic Epidemiology COVID-19

Genomic Epidemiology of (COVID-19) Maintained by the Nextstrain team, enabled by data from GISAID.

Sources for COVID-19 Information

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World Health Organization (WHO)

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Centers for Disease Control, US

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International Society for Infectious Diseases

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This Week in Virology (TWIV)

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