Weekly Clinical Updates

COVID-19: State-Level Data Report | Characteristics and Clinical Outcomes of Children and Adolescents Aged <18 Years Hospitalized with COVID-19 – Six Hospitals, United States, July-August 2021 | Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared with Previous Waves | CDC Advisory Committee on Immunization Practices panel endorsed Pfizer and BioNTech’s Covid booster shots for 12 to 15-years olds | Risk Factors for Severe COVID-19 Outcomes Among Persons Aged >18 years who completed a primary COVID19 vaccination series

CDC Updates and Shortens Recommended Isolation and Quarantine Period for General Population | Children and COVID-19: State-Level Data Report | Texas Children’s Hospital and Baylor College of Medicine COVID-19 Vaccine Technology Secures Emergency Use Authorization in India

Children and COVID-19: State Data Report | Duration of SARS-CoV-2 Natural Immunity and Protection against the Delta Variant: A Retrospective Cohort Study | Quarantine and Isolation | Frequently Asked Questions on the Emergency Use Authorization for Paxlovid for Treatment of COVID-19

• Outpatient COVID-19 Management Strategies in Children and Adolescents • SARS-CoV-2-specific memory B cells can persist in the elderly who have lost detectable neutralising antibodies • Science Brief: SARS-CoV-2 Infection-induced and Vaccine-induced Immunity • Azithromycin in patients with COVID-19: a systematic review and meta-analysis • Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19 • In non–critically ill patients with COVID-19, therapeutic anticoagulation improved survival to discharge without organ support • Africa's COVID-19 numbers surge, but hospital cases stay low • B.1.1.529 escapes the majority of SARS-CoV-2 neutralizing antibodies of diverse epitopes • mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant • Protection against Covid-19 by BNT162b2 Booster across Age Groups

• SARS-CoV-2 vaccine protection and deaths among US veterans • New phase 3 analyses show that a single dose of REGEN-CoV (Casirivimab and Imdevimab) provides long-term protection against COVID-19 • Pfizer’s novel COVID-19 oral antiviral treatment candidate reduced risk of hospitalization or death

• WHO estimate: 115,000 health workers have died from Covid-19, as calls for vaccine access grow • Virologic features of SARS-CoV-2 infection in children • COVID-19 Vaccination and Non–COVID-19 Mortality Risk • Association of Statins and 28-Day Mortality in Patients Hospitalized with SARS CoV-2 Infection • Assessment of Cognitive Function in Patients After COVID-19 Infection • Covid-19 Breakthrough Infections in Vaccinated Health Care Workers • Coronavirus (COVID-19) Update: FDA Takes Additional Actions on the Use of a Booster Dose for COVID-19 Vaccines • FACT SHEET FOR HEALTH CARE PROVIDERS: EMERGENCY USE AUTHORIZATION (EUA) OF REGEN-COV • Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial • Routine Vaccination Coverage — Worldwide, 2020 Antibody Testing Is Not Currently Recommended to Assess Immunity After COVID-19 Vaccination: FDA Safety Communication • The Flawed Science of Antibody Testing for SARS-CoV-2 Immunity