{"id":410868,"date":"2026-10-16T17:25:01","date_gmt":"2026-10-16T17:25:01","guid":{"rendered":"https:\/\/parasiteswithoutborders.com\/?p=410868"},"modified":"2026-10-27T17:33:19","modified_gmt":"2026-10-27T17:33:19","slug":"10-16-2026","status":"publish","type":"post","link":"https:\/\/parasiteswithoutborders.com\/es\/10-16-2026\/","title":{"rendered":"October 16, 2026"},"content":{"rendered":"<iframe title=\"Libsyn Player\" data-src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/43336754\/height\/90\/theme\/custom\/thumbnail\/yes\/direction\/backward\/render-playlist\/no\/custom-color\/a53939\/\" height=\"90\" width=\"100%\" scrolling=\"no\"  allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen src=\"about:blank\" class=\"lazyload\" data-load-mode=\"0\"><\/iframe>\n\t\t\t<a href=\"javascript:void(0)\" title=\"View Video Update\" target=\"_self\"  data-modal=  \"role=\"button\"\" aria-label=\"View Video Update\">\n\t\t\t\t\t\t\t\t\t\t\tView Video Update\n\t\t<\/a>\n\t\t\t<a href=\"https:\/\/parasiteswithoutborders.com\/wp-content\/uploads\/2026\/10\/TWiV-1366-Clinical-Update-with-Dr.-Daniel-Griffin.pdf\" title=\"VIEW TRANSCRIPT\" target=\"_blank\" rel=\"noopener\"  role=\"button\" aria-label=\"VIEW TRANSCRIPT\">\n\t\t\t\t\t\t\t\t\t\t\tVIEW TRANSCRIPT\n\t\t<\/a>\n\t<a href=\"https:\/\/www.nature.com\/articles\/s41587-026-03331-w\">Accelerated Discovery of Thermostable mRNA-lipid Nanoparticle Vaccines Using Data-efficient AI Biotechnology.<\/a><br \/>\nThe instability of mRNA\u2212lipid nanoparticles (LNPs) necessitates ultra-cold storage, limiting global distribution and their broader application in advanced delivery systems. Solid-state, water-free formulations enhance thermostability and enable integration into emerging delivery modalities such as microneedle patches. Previous efforts to stabilize mRNA\u2212LNPs have been constrained by narrow formulation scope and low-throughput screening methods. Here authors introduce Algorithm-Guided Experimental design for lipid Nanoparticle Thermostabilization (AGENT), an artificial intelligence (AI)-driven framework that couples high-throughput experimentation with Bayesian optimization to identify thermostable mRNA\u2212LNP formulations. AGENT extracts maximal information from sparse experimental datasets, enabling efficient formulation optimization in six iterations completed within one\u2009month. We stabilized mRNA vaccines with two clinically relevant LNPs representative of the Moderna (SM-102-based) and Pfizer-BioNTech (ALC-0315-based) compositions into solid-state formulations that retained 100% bioactivity after storage at 37\u2009\u00b0C for more than two\u2009months. In rodents and non-human primates, thermostable, solid-state vaccine formulations induced antigen-specific immune responses non-inferior to those elicited by intramuscular delivery of freshly prepared soluble vaccines.\n\t<a href=\"https:\/\/www.academia.edu\/3070-3530\/3\/2\/10.20935\/AcadMedHealth8289\">Characterizing Sleep Disturbance Phenotypes in Long COVID: An EHR-based Study from a Safety-net Hospital<\/a><br \/>\nThese are the results of\u00a0 a retrospective chart review of 496 adults evaluated between 2022 and 2023 at an urban safety-net hospital&#8217;s Long COVID clinic. Sleep disturbances were reported by 71.8% of participants. Insomnia (34.8%) and mixed phenotype (20.8%) were the most common, followed by hypersomnia (9.3%). Insomnia and mixed types were associated with pre-existing cases of anxiety, depression, chronic pain, and use of benzodiazepines, beta-blockers, and muscle relaxants. Mixed type was additionally associated with chronic heart disease (odds ratio (OR) = 5.0, <i>p<\/i> = 0.02), obstructive sleep apnea (OR = 3.2, <i>p<\/i> = 0.02), and chronic pulmonary disease (OR = 2.8, <i>p<\/i> &lt; 0.01). Hypersomnia was not linked to prior medical or psychiatric history but was predicted by PASC symptoms of post-exertional malaise (OR = 10.4, <i>p<\/i> &lt; 0.01), fatigue (OR = 6.1, <i>p<\/i> &lt; 0.01), dysautonomia (OR = 5.6, <i>p<\/i> = 0.02), and gait instability (OR = 9.2, <i>p<\/i> = 0.01).\u00a0 Insomnia in PASC aligned with pre-existing medical, psychiatric, and medication-related vulnerabilities, whereas hypersomnia appeared to emerge de novo alongside hallmark PASC symptoms. These divergent profiles suggest distinct pathophysiologic pathways and may inform more targeted diagnostic and treatment strategies.\n<a href=\"https:\/\/publications.ersnet.org\/content\/erj\/early\/2026\/10\/09\/1399300301162-2026\">Sputum and Oral Microbiota Profiles are Associated with Long COVID Severity and Phenotype Post-hospitalisation: A UK Multicentre, Prospective Cohort Study<\/a><br \/>\nIn this study adults were prospectively recruited to the longitudinal UK Post-hospitalisation COVID-19 study (PHOSP-COVID). Patients were grouped by previously described &#8220;severity clusters&#8221; (of ongoing health impairments) and symptom subgroups. Oral and sputum microbiota (at six\u2005months post-discharge) were characterised through 16S ribosomal RNA gene amplicon sequencing, and microbiota diversity was assessed. 771 participants had their microbiota assessed. Of participants with oral rinses and &#8220;severity cluster&#8221; assignment (mean age 57.5\u2005years), 278 out of 722 (38.5%) were women. The &#8220;very severe&#8221; cluster, in which disease was predominantly pulmonary in nature, was associated with a distinct microbiota profile post-COVID-19. Reduced lung function was associated with a distinct oral microbiota profile. Persistent neurocognitive symptoms were associated with a distinct oral microbiota profile, while gastrointestinal symptoms were associated with a distinct sputum microbiota profile. Microbiota keystone taxa shifted to a higher prevalence of lactic acid bacteria associated with worse health outcomes. Lactic acid bacteria abundance was associated with elevated blood inflammatory proteins.\n\t<h3>\n\t\t\t\tSituation Dashboards\n\t\t\t<\/h3>\n\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-300x89.png?lossy=1&strip=1&webp=1\" alt=\"World_Health_Organization_logo_logotype\" title=\"World_Health_Organization_logo_logotype\" itemprop=\"image\" data-srcset=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-300x89.png?lossy=1&amp;strip=1&amp;webp=1 300w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-1024x302.png?lossy=1&amp;strip=1&amp;webp=1 1024w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-768x227.png?lossy=1&amp;strip=1&amp;webp=1 768w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-1536x453.png?lossy=1&amp;strip=1&amp;webp=1 1536w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-2048x604.png?lossy=1&amp;strip=1&amp;webp=1 2048w\" data-sizes=\"auto\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/89;\" data-original-sizes=\"(max-width: 300px) 100vw, 300px\" \/>\n\t\t<h3>World Health Organization (WHO)<\/h3>\t\t\t\nNovel Coronavirus (COVID-19) Situation from World Health Organization (WHO)\n\t\t\t<a href=\"https:\/\/experience.arcgis.com\/experience\/685d0ace521648f8a5beeeee1b9125cd\" title=\"View Dashboard\" target=\"_blank\" rel=\"noopener\"  role=\"button\" aria-label=\"View Dashboard\">\n\t\t\t\t\t\t\tView Dashboard\n\t\t<\/a>\n\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/university-logo-small-horizontal-blue-no-clear-space-51c7fb4524-300x57.png?lossy=1&strip=1&webp=1\" alt=\"university-logo-small-horizontal-blue-no-clear-space-51c7fb4524\" title=\"university-logo-small-horizontal-blue-no-clear-space-51c7fb4524\" itemprop=\"image\" data-srcset=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/university-logo-small-horizontal-blue-no-clear-space-51c7fb4524-300x57.png?lossy=1&amp;strip=1&amp;webp=1 300w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/university-logo-small-horizontal-blue-no-clear-space-51c7fb4524-768x145.png?lossy=1&amp;strip=1&amp;webp=1 768w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/university-logo-small-horizontal-blue-no-clear-space-51c7fb4524.png?lossy=1&amp;strip=1&amp;webp=1 908w\" data-sizes=\"auto\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/57;\" data-original-sizes=\"(max-width: 300px) 100vw, 300px\" \/>\n\t\t<h3>Johns Hopkins University (JHU)<\/h3>\t\t\t\nCoronavirus COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at JHU\n\t\t\t<a href=\"https:\/\/gisanddata.maps.arcgis.com\/apps\/opsdashboard\/index.html#\/bda7594740fd40299423467b48e9ecf6\" title=\"View Dashboard\" target=\"_blank\" rel=\"noopener\"  role=\"button\" aria-label=\"View Dashboard\">\n\t\t\t\t\t\t\tView Dashboard\n\t\t<\/a>\n\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/1point3acres-300x83.png?lossy=1&strip=1&webp=1\" alt=\"1point3acres\" title=\"1point3acres\" itemprop=\"image\" data-srcset=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/1point3acres-300x83.png?lossy=1&amp;strip=1&amp;webp=1 300w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/1point3acres-1024x283.png?lossy=1&amp;strip=1&amp;webp=1 1024w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/1point3acres-768x212.png?lossy=1&amp;strip=1&amp;webp=1 768w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/1point3acres-1536x425.png?lossy=1&amp;strip=1&amp;webp=1 1536w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/1point3acres.png?lossy=1&amp;strip=1&amp;webp=1 1837w\" data-sizes=\"auto\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/83;\" data-original-sizes=\"(max-width: 300px) 100vw, 300px\" \/>\n\t\t<h3>COVID-19 in US and Canada<\/h3>\t\t\t\n1Point3Acres Real-Time Coronavirus (COVID-19) Updates in US and Canada with Credible Sources\n\t\t\t<a href=\"https:\/\/coronavirus.1point3acres.com\/\" title=\"View Dashboard\" target=\"_blank\" rel=\"noopener\"  role=\"button\" aria-label=\"View Dashboard\">\n\t\t\t\t\t\t\tView Dashboard\n\t\t<\/a>\n\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/image-300x76.png?lossy=1&strip=1&webp=1\" alt=\"image\" title=\"image\" itemprop=\"image\" data-srcset=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/image-300x76.png?lossy=1&amp;strip=1&amp;webp=1 300w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/image-768x195.png?lossy=1&amp;strip=1&amp;webp=1 768w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/image.png?lossy=1&amp;strip=1&amp;webp=1 866w\" data-sizes=\"auto\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/76;\" data-original-sizes=\"(max-width: 300px) 100vw, 300px\" \/>\n\t\t<h3>Genomic Epidemiology COVID-19<\/h3>\t\t\t\nGenomic Epidemiology of (COVID-19) Maintained by the Nextstrain team, enabled by data from GISAID.\n\t\t\t<a href=\"https:\/\/nextstrain.org\/ncov\" title=\"View Dashboard\" target=\"_blank\" rel=\"noopener\"  role=\"button\" aria-label=\"View Dashboard\">\n\t\t\t\t\t\t\tView Dashboard\n\t\t<\/a>\n\t<h3>\n\t\t\t\tSources for COVID-19 Information\n\t\t\t<\/h3>\n\t<a href=\"https:\/\/www.who.int\/\" target=\"_blank\" rel=\"noopener\" aria-label=\"Go to https:\/\/www.who.int\/\"><\/a>\n\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-300x89.png?lossy=1&strip=1&webp=1\" alt=\"World_Health_Organization_logo_logotype\" title=\"World_Health_Organization_logo_logotype\" itemprop=\"image\" data-srcset=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-300x89.png?lossy=1&amp;strip=1&amp;webp=1 300w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-1024x302.png?lossy=1&amp;strip=1&amp;webp=1 1024w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-768x227.png?lossy=1&amp;strip=1&amp;webp=1 768w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-1536x453.png?lossy=1&amp;strip=1&amp;webp=1 1536w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/World_Health_Organization_logo_logotype-2048x604.png?lossy=1&amp;strip=1&amp;webp=1 2048w\" data-sizes=\"auto\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/89;\" data-original-sizes=\"(max-width: 300px) 100vw, 300px\" \/>\n\t\t<h3>World Health Organization (WHO)<\/h3>\t\t\t\n\t<a href=\"https:\/\/www.cdc.gov\/\" target=\"_blank\" rel=\"noopener\" aria-label=\"Go to https:\/\/www.cdc.gov\/\"><\/a>\n\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2025\/10\/CDC-logo.png?lossy=1&strip=1&webp=1\" alt=\"U.S. Centers for Disease Control and Prevention\" title=\"U.S. Centers for Disease Control and Prevention\" itemprop=\"image\" data-srcset=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2025\/10\/CDC-logo.png?lossy=1&amp;strip=1&amp;webp=1 1200w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2025\/10\/CDC-logo-300x236.png?lossy=1&amp;strip=1&amp;webp=1 300w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2025\/10\/CDC-logo-1024x805.png?lossy=1&amp;strip=1&amp;webp=1 1024w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2025\/10\/CDC-logo-768x604.png?lossy=1&amp;strip=1&amp;webp=1 768w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2025\/10\/CDC-logo-15x12.png?lossy=1&amp;strip=1&amp;webp=1 15w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2025\/10\/CDC-logo.png?size=512x402&amp;lossy=1&amp;strip=1&amp;webp=1 512w\" data-sizes=\"auto\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1200px; --smush-placeholder-aspect-ratio: 1200\/943;\" data-original-sizes=\"(max-width: 1200px) 100vw, 1200px\" \/>\n\t\t<h3>Centers for Disease Control, US<\/h3>\t\t\t\n\t<a href=\"https:\/\/promedmail.org\/\" target=\"_blank\" rel=\"noopener\" aria-label=\"Go to https:\/\/promedmail.org\/\"><\/a>\n\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/ISID_logo.png?lossy=1&strip=1&webp=1\" alt=\"International Society for Infectious Diseases\" title=\"International Society for Infectious Diseases\" itemprop=\"image\" data-srcset=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/ISID_logo.png?lossy=1&amp;strip=1&amp;webp=1 816w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/ISID_logo-300x116.png?lossy=1&amp;strip=1&amp;webp=1 300w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/ISID_logo-768x296.png?lossy=1&amp;strip=1&amp;webp=1 768w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/ISID_logo-18x7.png?lossy=1&amp;strip=1&amp;webp=1 18w, https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/ISID_logo.png?size=512x198&amp;lossy=1&amp;strip=1&amp;webp=1 512w\" data-sizes=\"auto\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 816px; --smush-placeholder-aspect-ratio: 816\/315;\" data-original-sizes=\"(max-width: 816px) 100vw, 816px\" \/>\n\t\t<h3>International Society for Infectious Diseases<\/h3>\t\t\t\n\t<a href=\"http:\/\/www.microbe.tv\/twiv\/\" target=\"_blank\" rel=\"noopener\" aria-label=\"Go to http:\/\/www.microbe.tv\/twiv\/\"><\/a>\n\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/b1663976.assetcdn.net\/1663976\/wp-content\/uploads\/2020\/03\/twiv-logo.png?lossy=1&strip=1&webp=1\" alt=\"twiv-logo\" title=\"twiv-logo\" itemprop=\"image\" data-sizes=\"(max-width: 265px) 100vw, 265px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 265px; --smush-placeholder-aspect-ratio: 265\/86;\" \/>\n\t\t<h3>This Week in Virology (TWIV)<\/h3>","protected":false},"excerpt":{"rendered":"<p>Vaccination: AI Biotechnology | COVID: The Late Phase\/PASC\/Long COVID<\/p>","protected":false},"author":1,"featured_media":410863,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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