Clinical Updates

Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study | Multisystem Inflammatory Syndrome in Children (MIS-C) | Decreased SARS-CoV-2 viral load following vaccination

Full-dose blood thinners decreased need for life support and improved outcome in hospitalized COVID-19 patients | Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization | Single Dose Vaccination in Healthcare Workers Previously Infected with SARS-CoV-2

Novavax COVID-19 Vaccine Demonstrates 89.3% Efficacy in UK Phase 3 Trial | Johnson & Johnson Announces Single-Shot Janssen COVID-19 Vaccine Candidate Met Primary Endpoints in Interim Analysis of its Phase 3 ENSEMBLE Trial | SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

COVID-19 Symptoms: Longitudinal Evolution and Persistence in Outpatient Settings | The impact of Spike mutations on SARS-CoV-2 neutralization | Vitamin D Status is Associated With In-hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients

SARS-CoV-2 encephalitis is a cytokine release syndrome: evidence from cerebrospinal fluid analyses | Evolution of antibody immunity to SARS-CoV-2 | Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine | Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

SARS-CoV-2 Viral Load on Admission Is Associated With 30-Day Mortality | Cognitive deficits in people who have recovered from COVID-19 relative to controls: An N=84,285 online study | Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

Reports of “Long-COVID”, are rising: Attributes and predictors of “Long COVID” | Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity | More people are getting COVID-19 twice, suggesting immunity wanes quickly in some | Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19 | ApoE isoform-dependent SARS-CoV-2 neurotropism and cellular response

A distinct innate immune signature marks progression from mild to severe COVID-19 | Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19 | Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

Veterans Health Administration COVID-19 (VACO) Index for COVID-19 Mortality | V-safe After Vaccination Health Checker | COVID-19 Vaccines and Severe Allergic Reactions | FDA Issues Emergency Use Authorization for Second COVID-19 Vaccine | K reports new variant, termed VUI 202012/01

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: an interim analysis of four randomized controlled trials in Brazil, South Africa, and the UK | FDA issues Emergency Use Authorization for first COVID-19 vaccine