April 5, 2020

Clinical Reports

  • Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19
    Patients with PCR proven symptomatic COVID-19 infection hospitalized at University Hospital Munich from 29th February to 27th March 2020 (n=40) were analyzed for baseline clinical and laboratory findings. Patients requiring mechanical ventilation 13/40 (32.5%) did not differ in age, comorbidities, radiological findings, respiratory rate or qSofa score. However, elevated interleukin-6 (IL-6) was strongly associated with the need for mechanical ventilation (p=1.2·10- 5). In addition, the maximal IL-6 level (cutoff 80 pg/ml) for each patient during disease predicted respiratory failure with high accuracy (p=1.7·10-8, AUC=0.98). The risk of respiratory failure for patients with IL-6 levels of ≥ 80pg /ml was 22 times higher compared to patients with lower IL- 6 levels.

Antiviral Therapeutics

  • Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know
    Emergency Use Authorization was granted last week for hydroxychloroquine (HCQ) because of drug shortages in the U.S. largely due to hoarding and panic buying that may compromise the indicated use for patients with systemic lupus patients. Definitive clinical trials are listed in Clinicaltrials.gov and are underway and will report out soon.

    A randomized 30 patient control trial from Sudan University in Shanghai failed to demonstrate meaningful differences and highlights the need for properly powered clinical trials to answer a clear hypothesis to benefit patient care. 

Non-human Animal Infections

  • Tiger at New York's Bronx Zoo Tests Positive for Coronavirus
    Nadia, a 4-year-old Malayan tiger that tested positive, was screened for the COVID-19 disease after developing a dry cough along with three other tigers and three lions, the Wildlife Conservation Society, which manages the zoo, said in a statement. All of the cats are expected to recover, it said. They were likely infected from an asymptomatic keeper.

Situation Dashboards


World Health Organization (WHO)

Novel Coronavirus (COVID-19) Situation from World Health Organization (WHO)

Johns Hopkins University (JHU)

Coronavirus COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at JHU

COVID-19 in US and Canada

1Point3Acres Real-Time Coronavirus (COVID-19) Updates in US and Canada with Credible Sources

Genomic Epidemiology COVID-19

Genomic Epidemiology of (COVID-19) Maintained by the Nextstrain team, enabled by data from GISAID.

Sources for COVID-19 Information


World Health Organization (WHO)


Centers for Disease Control, US


International Society for Infectious Diseases


This Week in Virology (TWIV)

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