Weekly Clinical Updates

Children and COVID19: State Level Data Report | Comparison of outcomes from COVID infection in pediatric and adult patients before and after the emergence of Omicron – Retrospective Cohort Study | Infectious viral load in unvaccinated and vaccinated patients infected with SARS-CoV-2 WT, Delta and Omicron | Effectiveness of BNT162b2 (Pfizer-BioNTech) mRNA Vaccination Against Multisystem Inflammatory Syndrome in Children Among Persons Aged 12–18 Years — United States, July–December 2021 | Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

COVID-19: State-Level Data Report | Characteristics and Clinical Outcomes of Children and Adolescents Aged <18 Years Hospitalized with COVID-19 – Six Hospitals, United States, July-August 2021 | Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared with Previous Waves | CDC Advisory Committee on Immunization Practices panel endorsed Pfizer and BioNTech’s Covid booster shots for 12 to 15-years olds | Risk Factors for Severe COVID-19 Outcomes Among Persons Aged >18 years who completed a primary COVID19 vaccination series

CDC Updates and Shortens Recommended Isolation and Quarantine Period for General Population | Children and COVID-19: State-Level Data Report | Texas Children’s Hospital and Baylor College of Medicine COVID-19 Vaccine Technology Secures Emergency Use Authorization in India

Children and COVID-19: State Data Report | Duration of SARS-CoV-2 Natural Immunity and Protection against the Delta Variant: A Retrospective Cohort Study | Quarantine and Isolation | Frequently Asked Questions on the Emergency Use Authorization for Paxlovid for Treatment of COVID-19

• Outpatient COVID-19 Management Strategies in Children and Adolescents • SARS-CoV-2-specific memory B cells can persist in the elderly who have lost detectable neutralising antibodies • Science Brief: SARS-CoV-2 Infection-induced and Vaccine-induced Immunity • Azithromycin in patients with COVID-19: a systematic review and meta-analysis • Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19 • In non–critically ill patients with COVID-19, therapeutic anticoagulation improved survival to discharge without organ support • Africa's COVID-19 numbers surge, but hospital cases stay low • B.1.1.529 escapes the majority of SARS-CoV-2 neutralizing antibodies of diverse epitopes • mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant • Protection against Covid-19 by BNT162b2 Booster across Age Groups

• SARS-CoV-2 vaccine protection and deaths among US veterans • New phase 3 analyses show that a single dose of REGEN-CoV (Casirivimab and Imdevimab) provides long-term protection against COVID-19 • Pfizer’s novel COVID-19 oral antiviral treatment candidate reduced risk of hospitalization or death