July 2, 2026

Cervical Cancer Mortality Trends Following HPV Vaccination in England, 2001–24: An Analysis of Population-based Mortality Data
Authors analyzed population-based cervical cancer mortality data from England between 2001 and 2024 among women aged 20–24, 25–29, and 30–34 years. HPV vaccination coverage by birth cohort was obtained from official reports and used to estimate, for each age group and calendar year of death, the proportion of women who had been vaccinated. In women aged 20–24 years between 2020 and 2024, in whom vaccination coverage was around 88–90% at age 12–13 years, no deaths occurred, compared with 23·1 expected deaths based on historical rates, corresponding to a mortality reduction of 100% (95% CI 84–100). In earlier birth cohorts, who were offered vaccination up to age 18 years with coverage of around 63–87%, mortality reductions of 80% (51–94) in women aged 20–24 years in 2015–19, and 69% (55–79) in women aged 25–29 years in 2020–24 were observed. The relative risk reduction in vaccinated women was estimated from population-level data to be 100% (95% CI 81 to 100) in women aged 20–24 years, 100% (89 to 100) in those aged 25–29 years, and 63% (–13 to 100) in those aged 30–34 years.