Weekly Clinical Updates

Children and COVID19: State Level Data Report | Comparison of outcomes from COVID infection in pediatric and adult patients before and after the emergence of Omicron – Retrospective Cohort Study | Infectious viral load in unvaccinated and vaccinated patients infected with SARS-CoV-2 WT, Delta and Omicron | Effectiveness of BNT162b2 (Pfizer-BioNTech) mRNA Vaccination Against Multisystem Inflammatory Syndrome in Children Among Persons Aged 12–18 Years — United States, July–December 2021 | Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

COVID-19: State-Level Data Report | Characteristics and Clinical Outcomes of Children and Adolescents Aged <18 years hospitalized with covid-19 – six hospitals, united states, july-august 2021 | characteristics and outcomes of patients in south africa during the omicron wave compared previous waves cdc advisory committee on immunization practices panel endorsed pfizer biontech’s covid booster shots for 12 to 15-years olds risk factors severe among persons aged>18 years who completed a primary COVID19 vaccination series

CDC Updates and Shortens Recommended Isolation and Quarantine Period for General Population | Children and COVID-19: State-Level Data Report | Texas Children’s Hospital and Baylor College of Medicine COVID-19 Vaccine Technology Secures Emergency Use Authorization in India

Children and COVID-19: State Data Report | Duration of SARS-CoV-2 Natural Immunity and Protection against the Delta Variant: A Retrospective Cohort Study | Quarantine and Isolation | Frequently Asked Questions on the Emergency Use Authorization for Paxlovid for Treatment of COVID-19

• Outpatient COVID-19 Management Strategies in Children and Adolescents • SARS-CoV-2-specific memory B cells can persist in the elderly who have lost detectable neutralising antibodies • Science Brief: SARS-CoV-2 Infection-induced and Vaccine-induced Immunity • Azithromycin in patients with COVID-19: a systematic review and meta-analysis • Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19 • In non–critically ill patients with COVID-19, therapeutic anticoagulation improved survival to discharge without organ support • Africa's COVID-19 numbers surge, but hospital cases stay low • B.1.1.529 escapes the majority of SARS-CoV-2 neutralizing antibodies of diverse epitopes • mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant • Protection against Covid-19 by BNT162b2 Booster across Age Groups

• SARS-CoV-2 vaccine protection and deaths among US veterans • New phase 3 analyses show that a single dose of REGEN-CoV (Casirivimab and Imdevimab) provides long-term protection against COVID-19 • Pfizer’s novel COVID-19 oral antiviral treatment candidate reduced risk of hospitalization or death