Weekly Clinical Updates

FDA Updates on Paxlovid for Health Care Providers | SARS-CoV-2 Omicron Variant is as Deadly as Previous Waves After Adjusting for Vaccinations, Demographics, and Comorbidities | Comparative effectiveness over time of the mRNA-1273 (Moderna) vaccine and the BNT162b2 (Pfizer-BioNTech) vaccine

Children and COVID-19: State Date Report | Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalization in the UK: a prospective observational study | Moderna files for authorization of Its COVID-19 Vaccine in young children six months to under six years of age | Public health impact of covid-19 vaccines in the US: observational study | FDA approves first COVID-19 Treatment for Young Children | Veru Announces Presentation of Phase 2 Data of Sabizabulin for the Treatment of Hospitalized Severe COVID-19 Patients at High Risk for Acute Respiratory Distress Syndrome

COVID-19 Mortality and Vaccine Coverage — Hong Kong Special Administrative Region | Hospitalizations of Children Aged 5–11 Years with confirmed COVID | SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses | Pfizer and BioNTech Announce Data Demonstrating High Immune Response Following a Booster Dose of their COVID-19 Vaccine in Children | Safety, Immunogenicity and Antibody Persistence of a Bivalent Beta-Containing Booster Vaccine | Low-dose bivalent mRNA vaccine is highly effective against different SARS-CoV-2 variants in a transgenic mouse model | Intramuscular AZD7442 for Prevention of Covid-19

Children and COVID-19: State Date Report | Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance | Infectious viral load in unvaccinated and vaccinated individuals infected with ancestral, Delta or Omicron SARS-CoV-2 | Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination | Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization | Veru’s Novel COVID-19 Drug Candidate Reduces Deaths in Hospitalized Patients in Interim Analysis... | Comparison of Rapid Antigen Tests′ | SARS-CoV-2 infection in Africa: A systematic review and meta-analysis of standardised seroprevalence studies

Cardiac Complications After SARS-CoV-2 Infection and mRNA COVID-19 Vaccination — PCORnet, United States, January 2021–January 2022 | Clinical characteristics, activity levels and mental health problems in children with long coronavirus disease: a survey of 510 children | Short-term Outcomes of Corticosteroid Monotherapy in Multisystem Inflammatory Syndrome in Children | Protection by a Fourth Dose of BNT162b2 against Omicron in Israel | Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia

Effect of Early Treatment with Ivermectin among Patients with COVID-19 | Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19A Randomized Clinical Trial | Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19 | Prone positioning of patients with moderate hypoxaemia due to covid-19: multicenter pragmatic randomized trial (COVID-PRONE) | U.S. Food and Drug Administration authorized a second booster dose of either the Pfizer-BioNTech or the Moderna COVID-19 vaccines for older people and certain immunocompromised individuals