Clinical Updates

Pregnant woman holding her stomach as doctor gets ready to administer shot

August 10, 2023

Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study | Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts | Immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate: a randomised, double-blind, placebo-controlled, phase 2a trial

Young woman smiling with her sleeve rolled up as she gets an injection from a doctor on her upper arm

August 02, 2023

NIH has launched several phase 2 long-COVID treatment trials |
Effectiveness of Oral Nirmatrelvir/Ritonavir vs. Intravenous Three-Day Remdesivir in Preventing Progression to Severe COVID-19: A Single-Center, Prospective, Comparative, Real-Life Study |
Rapid Direct Detection of SARS-CoV-2 Aerosols in Exhaled Breath at the Point of Care |
Predicting COVID-19 Incidence Using Wastewater Surveillance Data, Denmark, October 2021–June 2022 |
Use of Wastewater Metrics to Track COVID-19 in the US published in JAMA Network Open |
Wastewater-based epidemiology predicts COVID-19-induced weekly new hospital admissions in over 150 USA countie | Association between duration of SARS-CoV-2 positivity and long COVID

Mature man with red patches on back visiting a dermatologist that is inspecting skin

July 30, 2023

Case Report of Leprosy in Central Florida, USA, 2022 | A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection | Delayed intubation associated with in-hospital mortality in patients with COVID-19 respiratory failure who fail heated and humified high flow nasal canula | Blood Group A Enhances SARS-CoV-2 Infection | Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort | Use of Respiratory Syncytial Virus Vaccines in Older Adults: Recommendations of the Advisory Committee on Immunization Practices — United States, 2023

Doctor wearing blue latex gloves administering injection to baby

July 20, 2023

Omicron subvariant BA.5 efficiently infects lung cells | The immunology of long COVID | FDA Approved a New Drug to Prevent RSV in Babies and Toddlers | COVID-19 scent dog research highlights and synthesis during the pandemic of December 2019-April 2023 | Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States

July 13, 2023

Exaggerated blood pressure elevation in response to orthostatic challenge, a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization | Long term follow-up of a multicentre cohort of COVID-19 patients with pulmonary embolism: Anticoagulation management and outcomes | Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals |
Repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection |
The Coronavirus Disease 2019 Rebound Study: A Prospective Cohort Study to Evaluate Viral and Symptom Rebound Differences in Participants Treated With Nirmatrelvir Plus Ritonavir Versus Untreated Controls | Risk of Cardiovascular Disease After COVID‐19 Diagnosis Among Adults With and Without Diabetes

July 05,2023

Autochthonous Leprosy in the United States | A systematic review to identify novel clinical characteristics of monkeypox virus infection and therapeutic and preventive strategies to combat the virus | Genome-wide Association Study of Long COVID | Two-year duration of immunity of inactivated poliovirus vaccine: A follow-up study in Pakistan in 2020 | Evaluation of novel oral polio vaccine type 2 SIA impact in a large outbreak of circulating vaccine-derived poliovirus in Nigeria | Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine | Oral Nirmatrelvir and Ritonavir for Covid-19 in Vaccinated, Non-Hospitalized Adults, Ages 18-50 Year | Vaccination Ameliorates Cellular Inflammatory Responses in SARS-CoV-2 Breakthrough Infections
|Performance of Rapid Antigen Tests to Detect Symptomatic and Asymptomatic SARS-CoV-2 Infection | High incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID: Implications for management and healthcare planning

June 29, 2023

Intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong | Female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders: a literature review | Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure: a systematic review based on eight high-quality randomized controlled trials | Guidance on Measles during the Summer Travel Season

June 22,2023

Updated COVID-19 Vaccines for Use in the United States Beginning in Fall 2023 | Prevention of COVID-19 Following a Single Intramuscular Administration of Adintrevimab: Results From a Phase 2/3 Randomized, Double-Blind, Placebo-Controlled Trial (EVADE) | Real-World Effectiveness of Nirmatrelvir/Ritonavir on Coronavirus Disease 2019 (COVID-19)–Associated Hospitalization Prevention: A Population-based Cohort Study in the Province of Quebec, Canada. | Coronavirus Disease 2019 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-Analysis of Individual Participant Data From 5 Randomized Trials |
Association of Culturable-Virus Detection and Household Transmission of SARS-CoV-2, California and Tennessee, 2020–2022

June 15, 2023

Anemia as a risk factor for disease progression in patients admitted for COVID-19 | Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome |
Post-COVID condition in patients with inflammatory rheumatic diseases | Persistent serum protein signatures define an inflammatory subcategory of long COVID |
The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome | Genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3 | Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza | Has COVID-19 Threatened Routine Childhood Vaccination? Insights From US Public Opinion Polls | Successful Treatment of Persistent Symptomatic Coronavirus Disease 19 (COVID-19) Infection with Extended Duration Nirmatrelvir/Ritonavir| Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT) | Metformin reduces SARS-CoV-2 in a Phase 3 Randomized Placebo Controlled Clinical Trial |
To Track Progress Toward Poliomyelitis Eradication — Worldwide, 2021–2022 |
Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study

June 08,2023

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection | Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms | Long COVID Clinical Phenotypes Up to Six Months After Infection Identified by Latent Class Analysis of Self-Reported Symptoms | Effectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes | Estimates of SARS-CoV-2 Seroprevalence and Incidence of Primary SARS-CoV-2 Infections Among Blood Donors, by COVID-19 Vaccination Status | Smart Thermometer–Based Participatory Surveillance to Discern the Role of Children in Household Viral Transmission During the COVID-19 Pandemic | Changing Severity and Epidemiology of Adults Hospitalized With Coronavirus Disease 2019 (COVID-19) in the United States After Introduction of COVID-19 Vaccines, March 2021–August 2022 |
National Trends in Anticoagulation Therapy for COVID-19 Hospitalized Adults in the United States: Analyses of the National COVID Cohort Collaborative | Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis

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