Daniel Griffin, MD, PhD

Universidad de Colorado, BA
Escuela de Medicina de la Universidad de Nueva York, MD
Escuela de Medicina Molecular Elmezzi, Instituto Feinstein, PhD

El Dr. Griffin es miembro de la División de Enfermedades Infecciosas e investigador asociado del Departamento de Bioquímica y Biofísica Molecular de la Universidad de Columbia. 

La investigación actual del Dr. Griffin se centra en el VIH-1 y en la latencia de las células madre, así como en la terapia genética de las células madre utilizando vectores retrovirales. Su otro trabajo incluye ivestigando el potencial de las células humanas B1 y los anticuerpos naturales en el desarrollo de malignidades asociadas al VIH. En el área de la salud global, el Dr. Griffin es un experto en enfermedades tropicales y se dedica a atender a pacientes en el extranjero, así como a inmigrantes y residentes en los Estados Unidos.  

El Dr. Griffin participa activamente en la educación médica y es uno de los presentadores y contribuyentes habituales de "Esta Semana en Parasitismo", un podcast sobre estudios de casos clínicos de parásitos eucariotas y enfermedades infecciosas.  

1. Gabriel Johnson; Sarah Lim; Daniel O Griffin; Xiong Wang; Lida R Etemad, The Impact or COVID-19 Monoclonal Antibody Therapy on Progression to Hospitalization in A Population with a High Percentage of the SARS-CoV-2 Alpha Variant Medical Research Archives Feb 2022 vol 10 issue 2.
2. Cuker, A., E. K. Tseng, R. Nieuwlaat, P. Angchaisuksiri, C. Blair, K. Dane, J. Davila, M. T. DeSancho, D. Diuguid, Griffin D. O., S. R. Kahn, F. A. Klok, A. I. Lee, I. Neumann, A. Pai, M. Righini, K. M. Sanfilippo, D. Siegal, M. Skara, D. R. Terrell, K. Touri, E. A. Akl, R. N. Al Jabiri, Y. N. Al Jabiri, A. M. Barbara, A. Bognanni, I. Bou Akl, M. Boulos, R. Brignardello-Petersen, R. Charide, M. Chan, L. E. Colunga-Lozano, K. Dearness, A. J. Darzi, H. Hussein, S. G. Karam, P. Kolb, R. Mansour, G. P. Morgano, R. Z. Morsi, G. Muti-Schünemann, M. K. Nadim, A. Noori, B. A. Philip, T. Piggott, Y. Qiu, Y. R. Benitez, F. Schünemann, A. Stevens, K. Solo, W. Wiercioch, R. A. Mustafa & H. J. Schünemann (2022) American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis. Blood Advances, Jan 21, 2022, 6, 664-671.
3. Johnson G, Lim S, Griffin DO, Wang X, Etemad LR. The Impact of COVID-19 Monoclonal Antibody Therapy on Progression to Hospitalization in A Population with a High Percentage of the SARS-CoV-2 Alpha Variant. JMRA Jan 2022 in press.
4. Cuker, A., E. K. Tseng, R. Nieuwlaat, P. Angchaisuksiri, C. Blair, K. Dane, J. Davila, M. T. DeSancho, D. Diuguid, D. O. Griffin, S. R. Kahn, F. A. Klok, A. I. Lee, I. Neumann, A. Pai, M. Pai, M. Righini, K. M. Sanfilippo, D. Siegal, M. Skara, K. Touri, A. A. E, I. Bou Akl, M. Boulos, R. Brignardello-Petersen, R. Charide, M. Chan, K. Dearness, A. J. Darzi, P. Kolb, L. E. Colunga-Lozano, R. Mansour, G. P. Morgano, R. Z. Morsi, A. Noori, T. Piggott, Y. Qiu, Y. Roldan, F. Schunemann, A. Stevens, K. Solo, M. Ventresca, W. Wiercioch, R. A. Mustafa & H. J. Schunemann (2021) American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19. Blood Adv, Oct 14, 2021, 5, 872-888.
5. Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dane K, Davila J, DeSancho MT, Diuguid DL, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Righini M, Sanfilippo K, Siegal DM, Skara M, Terrell DR, Touri K, Akl EA, Al Jabiri RN, Al Jabiri YN, Barbara AM, Bognanni A, Bou Akl I, Boulos M, Brignardello-Petersen R, Charide R, Chan M, Colunga-Lozano LE, Dearness KL, Darzi AJ, Hussein H, Karam SG, Kolb P, Mansour R, Morgano GP, Morsi RZ, Muti-Schünemann G, Nadim MK, Noori A, Philip BA, Piggott T, Qiu Y, Benitez YR, Schünemann F, Stevens A, Solo K, Wiercioch W, Mustafa RA, Schünemann HJ. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on post-discharge thromboprophylaxis. Blood Adv. 2021 February 28, 2021:bloodadvances.2021005945. doi: 10.1182/bloodadvances.2021005945. PMID: 34727173. https://pubmed.ncbi.nlm.nih.gov/34727173/
6. Binh T. Ngo, Paul Marik, Pierre Kory, Leland Shapiro, Raphael Thomadsen, Jose Iglesias, Stephen Ditmore, Marc Rendell, Joseph Varon, Michael Dubé, Neha Nanda, Gino In, Daniel Arkfeld, Preet Chaudhary, Vito M. Campese, Diana L. Hanna, David E. Sawcer, Glenn Ehresmann, David Peng, Miroslaw Smogorewski, April Armstrong, Rajkumar Dasgupta, Fred Sattler, Denise Brennan-Rieder, Cristina Mussini, Oriol Mitja, Vicente Soriano, Nicolas Peschanski, Gilles Hayem, Marco Confalonieri, Maria Carmela Piccirillo, Antonio Lobo-Ferreira, Iraldo Bello Rivero, Eivind H. Vinjevoll, Daniel Griffin, Ivan FN Hung The Time to Offer Treatments for COVID-19. Expert Opinion on Investigational Drugs , 23 April 2021, https://doi.org/10.1080/13543784.2021.1901883
7. Lyng, G, Sheils N, Kennedy C, Griffin DO, Berke E. Identifying Optimal COVID-19 Testing Strategies for School and Businesses: Balancing testing frequency, individual test technology, and cost. PLOS ONE 2021 Mar 25; 16(3): e0248783. doi:10.1371/journal.pone.0248783. PMID: 33764982
8. Daniel O. Griffin, Denise Brennan-Rieder, Binh Ngo, Pierre Kory, Marco Confalonieri, Jose Iglesias, Michael Dube, Neha Nanda, Daniel Arkfeld, Diana Hanna, David Sawcer, David Peng, Preet Chaudhary, Eivind H.Vinjevoll, Cristina Mussini, Oriol Mitjà, Vincente Soriano, Nicolas Peschanski, António Lobo-Ferreira,  Iraldo B. Rivero, Marc Rendell, Stephen Ditmore, Rajkumar Dasgupta, Gino In, Gilles Hayem,  Leland Shapiro, Joseph Varon, Maria Carmela Piccirillo, Paul Marik. The Importance of Understanding the Stages of COVID-19 in Treatment and Trials. AIDS Rev 2021 2021/02/09. DOI: 10.24875/AIDSRev.200001261.
9. Griffin DO, Jensen A, Khan M, Chin J, Chin K, Saad J, Parnell R, Awwad C, Patel D Cytokine storm of a different flavor: the different cytokine signature of SARS-CoV2 the cause of COVID-19 from the original SARS outbreak -Journal of Global Antimicrobial Resistance (2020) -doi: https://doi.org/10.1016/j.jgar.2020.11.005
10. Shimotsu ST, Johnson ARL, Berke EM, Griffin DO. COVID-19 infection control measures in long-term care facility, Pennsylvania, USA. Emerg Infect Dis. 2021 Feb 2 https://doi.org/10.3201/eid2702.204265
11. Adam Cuker, Eric Tseng, Robby Nieuwlaat, Panted Angchaisuksiri, Clifton Blair, Kathryn Dane, Jennifer Davila, Maria DeSancho, David Diuguid, Daniel Griffin, Susan Kahn, FA Klok, Alfred Lee, Ignacio Neumann, Ashok Pai, Menaka Pai, Marc Righini, Kristen Sanfilippo, Deborah Siegal, Mike Skara, Kamshad Touri, Elie Akl, Imad Bouakl, Mary Boulos, Romina Brignardello-Petersen, Rana Charide, Matthew Chan, Karen Dearness, Andrea Darzi, Philipp Kolb, Luis Lozano, Razan Mansour, Gian Paolo Morgano, Rami Morsi, Atefeh Noori, Thomas Piggott, Yuan Qiu, Yetiani Roldan, Finn Schünemann, Adrienne Stevens, Karla Solo, Matthew Ventresca, Wojtek Wiercioch, Reem A. Mustafa, and Holger J. Schünemann. American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19. Blood Adv 2021; 5 (3): 872–888. doi:  https://doi.org/10.1182/bloodadvances.2020003763
12. Griffin DO, Jensen A, Khan M, Chin J, Chin K, Saad J, Parnell R, Awwad C, Patel D. Arterial thromboembolic complications in COVID-19 in low-risk patients despite prophylaxis. Br J of Haematol 2020 May 6. Doi: 10.1111/bjh. 16792
13. Griffin DO, Jensen A, Khan M, Chin J, Chin K, Saad J, Parnell R, Awwad C, Patel D. Pulmonary embolism and increased levels of D-dimer in patients with coronavirus disease. Emerg Infect Dis. 2020 Aug. https://doi.org/10.3201/eid2608.201477
14. Sebrow J, Goff S.P., Griffin DO. Successfully Transfected Primary Peripherally Mobilized Human CD34+ Hematopoietic Stem and Progenitor Cells (HSPCs) Demonstrate Increased Susceptibility to Retroviral Infection - Virology Journal (2020) 17:22 DOI:10.1186/s12985-020-1297-3
15. Natasha Spottiswoode, M.D., D.Phil., Susan L. Bartlett, D.V.M., Dipl. A.C.Z.M., Kenneth J. Conley, D.V.M., Dipl. A.C.V.P., Tracie A. Seimon, Ph.D.  Daniel O. Griffin M.D., Ph.D., John M. Sykes IV, D.V.M., Dipl. A.C.Z.M. ANALYSIS OF PLASMODIUM LINEAGES IDENTIFIED IN CAPTIVE PENGUINS (SPHENISCIFORMES spp.), EIDERS (SOMATERIA spp.), AND INCA TERNS (LAROSTERNA INCA) IN A NORTH AMERICAN ZOOLOGICAL COLLECTION - Journal of Zoo and Wildlife Medicine (2019)12/2019
16. Griffin DS,Muhlbauer G, and Griffin DO. Adolescents trust physicians for vaccine information more than their parents or religious leaders. Heliyon 4 (2018) e01006. DOI: 10.1016/j.heliyon.2018.201006.
17. Griffin DO, Metzger M, Bharti B, Dharsee A, Rico JC, McGowan J. Co-infection with Hepatitis C Virus Increases Mortality in HIV-1 Infected Patients Through Increased Liver-Related Deaths Rather Than By Increasing Malignancy Related Deaths. J AIDS and Clin Res 2016, 7:4.DOI: 10.1097/QAD.0000000000001646.
18. Griffin, DO and Goff, S.P. Restriction of HIV-1-based Lentiviral Vectors in Adult Primary Marrow-Derived and Peripheral Mobilized Human CD34+ Hematopoietic Stem and Progenitor Cells Occurs Prior to Viral DNA Integration. Retrovirology 2016 (1);14. PMID 26945863, DOI: 10.1186/s12977-016-0246-0.
19. Rico JC, Schwartz RM, McGowan J, Griffin DO. The Presence of a Malignant Comorbidity is a Significant Predictor of Increased 30-Day Hospital Readmission Rates in HIV-1 Infected Individuals. J AIDS and Clin Res 2015, 6:12. DOI: 10.4172/2155-6113.1000532
20. Griffin DO, Metzger M, Poeth K, Deng K, Dharsee A, Rico JC, McGowan J. Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy. OFID 2015,2:ofv147. DOI: 10.1093/ofid/ofv147
21. Cui X., Zhang L., Magli A. R., Catera R., Yan X. J., Griffin DO, Rothstein T. L., Barrientos J., Kolitz J. E., Allen S. L., Rai K. R., Chiorazzi N. and Chu C. C. (2015) Cytoplasmic myosin exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability. Leukemia 2015 July 29. DOI: 10.1038/leu.2015.204.
22. Griffin, DO and Goff, S.P. HIV-1 is Restricted Prior to Integration in Primary Cord-Derived Human CD34+ Cells. J Virol 2015 May 20. Pii JVI.0.01044-15.
23. Griffin, DO, Dharsee, A., Rico, J.C., McGowan, J., The Increasing Frequency of Deaths Due to Malignancy in HIV+ Patients is Associated with Poor Viral Suppression, Low CD4 Counts, Decreased Vitamin D Levels and Integrase Inhibitor Therapy. Journal of Health Science 2 (2014) 240-247. DOI: 10.17265/2328-7136/2014.05.005
24. Griffin, DO and T.L. Rothstein, Human "orchestrator" CD11b(+) B1 cells spontaneously secrete IL-10 and regulate T cell activity. Molecular Medicine, 2012 Sep 7;18:1003-8. PMID 22634719
25. Griffin, DO and T.L. Rothstein, Human B1 cell Frequency: Isolation and Analysis of Human B1 Cells. Frontiers in Immunology, 2012. 3(122): p. 1-10. Epub 2012 May25. PMID 22634719
26. Griffin, DO, T. Quach, F. Batliwalla, N.E. Holodick, and T.L. Rothstein. 2012. Human CD11b⁺ B1 cells are not monocytes: A reply to “Gene profiling of CD11b⁺ and CD11b^- B1 cell subsets reveals potential cell sorting artifacts". J Exp Med. 209:434-436. PMID 22412176
27. Griffin, DO, and T.L. Rothstein. 2011. A small CD11b+ human B1 cell subpopulation stimulates T cells and is expanded in lupus. J Exp Med. 208:2591-8. PMID 22110167
28. Griffin, DO, N.E. Holodick, and T.L. Rothstein. 2011. Human B1 cells are CD3-: A reply to "A human equivalent of mouse B-1 cells?" and "The nature of circulating CD27+CD43+ B cells". J Exp Med. 208:2566-9. PMID 22184682
29. Griffin, DO, N.E. Holodick, and T.L. Rothstein. 2011. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70-. J Exp Med. 208:67-80. PMID 21220451
30. Doing A, Griffin D, Jacobson JA, Amber IJ, Gilbert E. 2001, B-cell function in chronic heart failure: antibody response to pneumococcal vaccine. J Card Fail 7:318-21. PMID 11782854

1. Griffin DO. The Challenge of Malignancies in HIV-1, Beyond Immune Activation and Back to Decreased Immune Surveillance. J AIDS and Clin Res 2016, 7:1 p535 doi:10.4172/2155-613.1000535.
2. Rothstein, T.L., D.O. Griffin, N.E. Holodick, T.D. Quach, and H. Kaku. 2013. Human B-1 cells take the stage. Annals of the New York Academy of Sciences 2013 May;1285:97-114. PMID 23692567

1. Committee on Infectious Diseases; American Academy of Pediatrics; Red Book 2021 (Primary contributor and leading content expert for the chapters: Parasitic Diseases-150 and Enterobius vermicularis-159.)
2. Long S, Prober C, Fischer M (Griffin-Chapter on Tissue Nematodes). Principles and Practice of Pediatric Infectious Diseases, 6^th Edition 2020 Expert Consult.
3. Griffin DO. The Medical Handbook for Limited Resource Settings V1. 2019 Parasites Without Borders, Inc, NY.
4. Despommier D, Griffin DO, Gwadz R, Hotez J, Knirsch C. Enfermedades Parasitarias Sexta Edoción, 2017 Parasites Without Borders, Inc, NY.
5. Despommier D, Griffin DO, Gwadz R, Hotez J, Knirsch C. Parasitic Diseases 7^th Edition, 2019 Parasites Without Borders, Inc, NY.
6. Despommier D, Griffin DO, Gwadz R, Hotez J, Knirsch C. Parasitic Diseases 6^th Edition, 2017 Parasites Without Borders, Inc, NY.
7. Long S, Prober C, Fischer M (Griffin-Chapter on Tissue Nematodes). Principles and Practice of Pediatric Infectious Diseases, 5^th Edition 2017 Expert Consult.
8. Griffin DO Babbitt NR, Collins D, Diamond LH, Drury BM, Duke JR, Heichert S, Jacobs BR, Loveys A, McColm D, Ott J, Schulte M, Wise PB, 2010, Go-Live: Smart Strategies from Davies Award-Winning EHR Implementations, Healthcare Information and Management Systems.

1. Griffin, DO 2018. The diagnosis of symptomatic acute antiretroviral syndrome during the window period with antigen/antibody testing and HIV viral load. IDCases, 2018 May 23.

2. Griffin, DO, Donaghy, H.J., Edwards, E. 2014. Management of Serology Negative Human Hepatic Hydatidosis (Caused by Echinococcus Granulosis) in a Young Woman from Bangladesh in a Resource Rich Setting: A Case Report. IDCases, 2014 March 2.