Weekly Clinical Updates

Adverse Childhood Experiences During the COVID-19 Pandemic and Associations with Poor Mental Health and Suicidal Behaviors Among High School Students | Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales | Successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials | Prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic

A healthcare-associated infection with Monkeypox virus of a healthcare worker during the 2022 outbreak | Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomized ascending dose phase I trial | Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir Treatment | Early outpatient treatment with remdesivir in patients at high risk for severe COVID-19: a prospective cohort study

Possible Occupational Infection of Healthcare Workers with Monkeypox Virus, Brazil | Protection of SARS-CoV-2 natural infection against reinfection with the BA.4 or BA.5 Omicron subvariants | Rates of Monkeypox Cases by Vaccination Status | Paxlovid Significantly Reduces COVID-19 Hospitalizations and Deaths | Nirmatrelvir–Ritonavir and Viral Load Rebound in Covid-19

Increase in Acute Respiratory Illnesses Among Children and Adolescents Associated with Rhinoviruses and Enteroviruses, Including Enterovirus D68 — United States, July–September 2022 | Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 | Long Covid—An Update for Primary Care | A distinct symptom pattern emerges for COVID-19 long-haul: A Nationwide Study | SARS-CoV-2 Secondary Attack Rates in Vaccinated and Unvaccinated Household Contacts during Replacement of Delta with Omicron Variant, Spain | Breakthrough Infection by SARS-CoV-2 Delta and Omicron Variants Elicited Immune Response Comparable to mRNA Booster Vaccination

Monkeypox in a Young Infant — Florida, 2022 | Health Care Personnel Exposures to Subsequently Laboratory-Confirmed Monkeypox Patients — Colorado, 2022 | Public Health Response to a Case of Paralytic Poliomyelitis in an Unvaccinated Person and Detection of Poliovirus in Wastewater — New York, June–August 2022 | Association of COVID-19 with New-Onset Alzheimer’s Disease | Impact of mandatory vaccination of healthcare personnel on rates of influenza and other viral respiratory pathogens | Monkeypox in Patient Immunized with ACAM2000 Smallpox Vaccine During 2022 Outbreak

Severe Respiratory Illnesses Associated with Rhinoviruses and/or Enteroviruses Including EV-D68 – Multistate, 2022 | Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae | Impact of COVID-19 vaccination on the risk of developing long-COVID and on existing long-COVID symptoms: A systematic review | Effects of Vaccination and Previous Infection on Omicron Infections in Children | COVID-19-Associated Hospitalizations Among Vaccinated and Unvaccinated Adults 18 Years or Older in 13 US States, January 2021 to April 2022 | Effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada